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. 2021 Aug 24;13(17):4266. doi: 10.3390/cancers13174266

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Piperlongumine significantly inhibited human thyroid cancer cell growth in vivo. IHH-4-bearing mice were treated with either dimethyl sulfoxide (DMSO) (n = 5) or PL (n = 5/group). (A) Representative images of excised tumors from each group. (B) Tumor volume and (C) tumor weight were measured to reflect tumor growth in vivo. (D) Hematoxylin and eosin staining to determine cellular pathology and immune cell infiltration. 200× magnification. (E) Apoptosis in tumors was measured by terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) staining, and the brown staining indicates apoptotic cells. 40× magnification. DMSO was used as a negative control. * indicates p < 0.05. ** indicates p < 0.01.