Table 2. Computation of CC of synthetic Fig. 1 and computation of spreadability rate of selected top 10 spreader nodes by the SIS model.

Rank	Proteins	Closeness centrality	Sum of SIS spreadability rate of top 10 nodes
1	1	0.085	1.94
2	5	0.083
3	2	0.082
4	4	0.082
5	23	0.081
6	3	0.081
7	21	0.081
8	22	0.081
9	7	0.08
10	15	0.08
11	16	0.08	–
12	19	0.079
13	14	0.079801
14	9	0.079602
15	20	0.079602
16	6	0.079602
17	8	0.079404
18	17	0.078818
19	10	0.078624
20	11	0.078049
21	12	0.078049
22	13	0.078049
23	18	0.07767
24	24	0.041558
25	32	0.041237
26	28	0.041237
27	30	0.041237
28	25	0.041237
29	27	0.041237
30	31	0.041184
31	33	0.041184
32	29	0.040921
33	26	0.040921