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. 2021 Aug 23;12:681206. doi: 10.3389/fgene.2021.681206

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Copyright © 2021 Chen, Zhang, Li and Ouyang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LISA2 analysis of the development of hematopoietic stem cells (HSC) using single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) data. (A) The cell type visualization in UMAP. (B) The clustering results on UMAP. (C) Pie tree plot shows the cell types and trajectory. (D) The pseudotime plot in UMAP. (E) The 3D-ISOMAP and trajectory visualization. (F) Cell cluster tree plot shows the differentiation trajectory of HSC. All cell types include lymphoid multipotent progenitors (LMPPs), granulocyte monocyte progenitors (GMPs), plasmacytoid dendritic cells (pDCs), lymphoid progenitor cells (CLPs), common myeloid progenitors (CMPs), megakaryocytic cells (MEP), multipotent progenitors (MPPs), and monocytic cells (mono).