Figure 5.
Evolution of pHe evaluated by CEST-MRI. Typical images and histograms of distribution of pHe values recorded before and after vehicle administration (left), before and after UK-5099 administration (right) (daily IP injection during 4 days, 3 mg/kg). Images are recorded on the same mice. Note that the pHe values remained rather identical in the control group while there is a clear shift in pHe towards more acidic values. Note also the large heterogeneity of pHe values recorded after the UK-5099 treatment.
