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. 2021 Aug 26;11:627811. doi: 10.3389/fonc.2021.627811

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Copyright © 2021 Escuin, López-Vilaró, Mora, Bell, Moral, Pérez, Arqueros, García-Valdecasas, Ramón y Cajal, Lerma and Barnadas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed miRNAs according to the SLN status. (A–D) The volcano plots show differentially expressed miRNAs in plasma samples according to the patients’ locoregional metastatic status as indicated. Only significant miRNAs with corrected q values < 0.05 are shown in the plots (red dots). The data show the relationship between non-adjusted p values (y-axis) and the fold change (x-axis) between the experimental groups. (E) Heat map and hierarchical clustering analyzed by samples and miRNAs. The analysis was performed using the 15 miRNAs differentially expressed between patients with positive and negative SLNs. Each row represents one miRNA and each column represents one sample. The color scale shows the expression level above (red) or below (green) the mean.