Table 7.
Summary of key literature reports on the effect of lung dose.
| First author, publication year | N | Prescribed dose (Gy)/fx | Lung dose (Gy) | Dose rate (cGy/min) | Dose rate finding |
|---|---|---|---|---|---|
| Petersen, 1992 (87) | 36^ | 12 or 16/6 BID, 17/7 BID | Prescription | 8 | PT or IPS in 50% of patients receiving 17Gy as compared to 15% after 16Gy. |
| Sampath, 2005 (91) | 1090* | Up to 15.6 | Up to 15.6 | 3-41 | Lung dose was associated with PT in patients receiving 1 fx/day – 2.3% if ≤6 Gy to lungs. |
| Soule, 2007 (57) | 181≠ | 12 or 13.6 (1.5-1.7 Gy/fx bid) | 6 to >13.6 | 12 | Lung dose reduction should be employed primarily to decrease mortality from PT in high-risk patients. |
| Weschler, 1990 (30) | 43^ | 6/4 BID (TLI) or 12/6 BID (TBI) | 6 or 12 | 15-18 | IPS occurred in 26% without lung shielding as compared to 0% with partial lung shielding. |
bid, twice a day; fx, fraction; IP, interstitial pneumonitis; IPS, idiopathic pneumonia syndrome; NR, not reported; PT, pulmonary toxicity; TLI: total lymphoid irradiation; *ages not specified; ^ adults and children ≠adults and adolescents.