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Functional analysis of FANCA mutant proteins
| Protein | FA-A cell complementation | FANCC binding | Nuclear localization | FANCG binding |
|---|---|---|---|---|
| Wild-type FANCA | + | + | + | + |
| FANCA-ΔNLS | − | − | − | − |
| SV40T-FANCA | − | − | + | − |
| FANCA-NLS-mut2 | − | − | − | − |
| FANCA-ΔXho | − | − | − | + |
| FANCA(H1110P) | − | − | − | + |
| FANCA(R1117G) | − | − | − | + |
