Fig. 5.

RMT P. chabaudi blood-stage infections trigger a stronger inflammatory response in the spleen.

Spleen lysates were prepared from C57Bl/6J mice infected with 10⁵ RMT (blue symbols) or SBP-iRBCs (pink symbols) or from naïve controls at different days post-infection (shown are day 5 and 7) and investigated with a cytokine/chemokine protein array. Graphs depict protein content expressed as pg/ml for cytokines involved in myeloid cell proliferation and recruitment (A), myeloid cell activation (B) and T cell activation (C). Graphs illustrate data from one experiment with 6 mice/group. The dashed areas denote the protein content of uninfected control samples. Transmission groups were compared per day via a nested ANOVA (see materials and methods section and Supplementary Table 5). All comparisons shown have a p-value below 0.05.