Fig. 7.

IFNγ-signalling, more specifically in myeloid cells, contributes to the anti-parasite response with RMT parasites.

Course of a P. chabaudi RMT blood-stage infection in IFNγR1 knockout (KO) mice (A–B) or in conditional LysM^CreIFNγR2^fl/fl(C), CD11c^CreIFNγR2^fl/fl(D), CD4^CreIFNγR2^fl/fl(E), or CD19^CreIFNγR2^fl/fl(F) knockout mice infected with 10⁵ RMT-iRBCs (A, C–F) or SBP-iRBCs (B). Each graph in panel C–F compares heterozygous experimental mice (Cre+/-, open symbols) with their wildtype littermates (Cre−/−, closed symbols) or heterozygous Cre mice without the IFNγR2^fl/fl (black). The graphs show mean (+/- SEM) of percentage parasitaemia calculated from log-transformed data. Shown are pooled data from two individual experiments (n = 8–10 mice; A-B), four experiments (n = 14–17 mice; C), three experiments (n = 4–17 mice; D), four experiments (n = 7–17 mice; E) or from four experiments (n = 20–21 mice; F).