Table 1. Summary of interaction results for all cohorts.

Results of GKGxSmk model for all traits in GS18K and meta-analysis of the recruitment centre-based sub-cohorts in UK Biobank. The table shows, for each trait, the proportion of the phenotypic variance explained (Var), its standard error (SE), the log-likelihood ratio test P value (LRT P, only for the interaction), the meta-analysis P value (P), for each of the components in the model: Genetic (G), Kinship (K) and Genome-by-Smoking interaction (GxSmk). Highlighted P values indicate nominally significant results for the GxSmk component.

Trait	Source	GS18K			UKB Meta Analysis
		Var	SE	LRT P	Var	SE	P
Height	G	0.483	0.022		0.629	0.009
Height	K	0.429	0.024		0.328	0.006
Height	GxSmk	0.012	0.014	0.2041	0.001	0.003	0.7640
Weight	G	0.270	0.024		0.355	0.007
Weight	K	0.302	0.027		0.242	0.018
Weight	GxSmk	0.049	0.021	0.0098	0.022	0.008	0.0050
BMI	G	0.258	0.024		0.318	0.008
BMI	K	0.286	0.028		0.236	0.021
BMI	GxSmk	0.039	0.021	0.0336	0.025	0.007	0.0009
Waist	G	0.181	0.024		0.261	0.004
Waist	K	0.313	0.028		0.214	0.021
Waist	GxSmk	0.023	0.022	0.1534	0.017	0.007	0.0119
Hips	G	0.212	0.024		0.296	0.009
Hips	K	0.271	0.028		0.179	0.028
Hips	GxSmk	0.027	0.023	0.1185	0.020	0.007	0.0048
WHR	G	0.130	0.023		0.217	0.005
WHR	K	0.198	0.027		0.151	0.013
WHR	GxSmk	0.019	0.023	0.2011	0.012	0.006	0.0437
Fat%	G	0.236	0.025		0.301	0.006
Fat%	K	0.241	0.028		0.224	0.013
Fat%	GxSmk	0.059	0.023	0.0036	0.021	0.005	0.0000
HDL	G	0.250	0.024		NA	NA
HDL	K	0.265	0.027		NA	NA
HDL	GxSmk	0.076	0.022	0.0002	NA	NA