Table 3.

Top genes with myeloid leukemia or other immune-related functions

Gene	Type	Description
ZNF770	Myeloid leukemia	This transcription factor’s binding motif is enriched in gene regulatory elements which are associated with AML relapse (Wiggers et al., 2019).
RNF11	Myeloid leukemia	This gene is differentially expressed between chronic phase CML and blast crisis CML (Jiang et al., 2013).
C9orf47	Myeloid leukemia	This gene is differentially expressed between NUP98-KDM5A+ pediatric AML and NUP98-KDM5A- pediatric AML (Noort et al., 2020).
PRDM2	Myeloid leukemia	PRDM2 expression is reduced in AML compared to normal bone marrow and is downregulated during CML progression (Lakshmikuttyamma et al., 2009; Sasaki et al., 2002). The repression of PRDM2 is involved in insulin-like growth factor-1 signaling activation in CML blast crisis cell lines (Pastural et al., 2007).
C20orf197	Other immune	This gene is differentially expressed between NUP98-KDM5A+ pediatric AML and NUP98-KDM5A- pediatric AML (Noort et al., 2020).
CEBPD	Other immune	The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.
SART3	Other immune	The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication.
GPR35	Other immune	This gene is expressed by monocytes and mast cells (Amir et al., 2018).

Note: Genes are ranked by SCCA coefficient magnitude. Unless cited, descriptions are provided by NCBI.