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. 2021 Mar 3;37(17):2617–2626. doi: 10.1093/bioinformatics/btab143

Table 3.

Top genes with myeloid leukemia or other immune-related functions

Gene Type Description
ZNF770 Myeloid leukemia This transcription factor’s binding motif is enriched in gene regulatory elements which are associated with AML relapse (Wiggers et al., 2019).
RNF11 Myeloid leukemia This gene is differentially expressed between chronic phase CML and blast crisis CML (Jiang et al., 2013).
C9orf47 Myeloid leukemia This gene is differentially expressed between NUP98-KDM5A+ pediatric AML and NUP98-KDM5A- pediatric AML (Noort et al., 2020).
PRDM2 Myeloid leukemia PRDM2 expression is reduced in AML compared to normal bone marrow and is downregulated during CML progression (Lakshmikuttyamma et al., 2009; Sasaki et al., 2002). The repression of PRDM2 is involved in insulin-like growth factor-1 signaling activation in CML blast crisis cell lines (Pastural et al., 2007).
C20orf197 Other immune This gene is differentially expressed between NUP98-KDM5A+ pediatric AML and NUP98-KDM5A- pediatric AML (Noort et al., 2020).
CEBPD Other immune The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.
SART3 Other immune The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication.
GPR35 Other immune This gene is expressed by monocytes and mast cells (Amir et al., 2018).

Note: Genes are ranked by SCCA coefficient magnitude. Unless cited, descriptions are provided by NCBI.