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. 2021 Sep 9;16(9):e0252849. doi: 10.1371/journal.pone.0252849

Fig 4. Dominant linear epitopes in COVID-19 mRNA vaccine recipients.

Fig 4

The relative IgG binding (average PIWAS, Y-axes) to different linear epitopes (spike amino acid number, X-axis) is highlighted for the C-terminal domains of S1 (A) and S2 (B). Data are from N = 20 Pfizer-BioNTech, N = 8 Moderna vaccine recipients, and N = 5 prior COVID-19 patients that received either Pfizer or Moderna vaccine as labeled in the key in upper right. The red line corresponds to the 95% quantile PIWAS score for a prior cohort of COVID+ subjects [12]. Note the highest PIWAS scores for LE-1 and LE-2 as labeled and limited vaccine induced IgG towards fusion peptide region, aa 788–806 [30].