Skip to main content
. Author manuscript; available in PMC: 2022 Feb 12.
Published in final edited form as: Nat Immunol. 2021 Aug 12;22(9):1152–1162. doi: 10.1038/s41590-021-00987-1

Figure 8. Tcf-7 is downregulated in CRC tumor-infiltrating Treg-cells.

Figure 8.

Publicly available scRNA-seq data from 12 CRC patients was analyzed, focusing on the Treg-cells from paired peripheral blood mononuclear cells (PBMC), tumor, and adjacent normal tissues. (a) Violin plots showing the expression of Tcf7 in Treg-cells from peripheral blood (PBMC), adjacent normal and tumor tissues. Data is sourced from GSE108989. Number of Treg-cells in each group is indicated in parenthesis. **** p<0.0001 by one-way ANOVA test. (b-d) GSEA plots showing highly expressed genes in Treg-cells, (b) comparing TH17 cell differentiation genes in tumor infiltrating to healthy tissue infiltrating Treg-cells, (c) comparing TH17 cell differentiation genes in tumor infiltrating to PBMC Treg-cells (d) comparing IL-17 signaling pathway in tumor infiltrating to PBMC Treg-cells, as designated. NES: Normalized enrichment scores.