Table 1.

Cross-Cutting Nonpharmacologic Biobehavioral Interventions

CBT [16,87,103]	CBT includes strategies to increase adaptive behavior and address unhelpful thought patterns. Exposure, cognitive restructuring, relaxation techniques, and coping skills training are common CBT-based interventions. CBT has a strong evidence base for depression and anxiety, and CBT-based interventions are effective for fatigue and pain. CBT for insomnia (CBT-I) is the gold standard treatment for insomnia.
Mindfulness-based interventions (MBIs) [16, 65,84,144]	MBIs increase adaptive behavior by cultivating awareness and acceptance of one’s current experience, including feelings, thoughts, and bodily sensations. Mindfulness-based stress reduction, yoga, meditation, and tai chi are MBIs that have been shown to be effective for fatigue, sleep disturbance, and depression.
Exercise [16, 68,84,86-89]	Exercise interventions include both aerobic and strength training approaches and have a growing evidence base for cancer-related fatigue as well as depression, anxiety, pain, and insomnia. The American College of Sports Medicine has developed materials to assist providers in prescribing exercise to cancer patients, available at https://www.exerciseismedicine.org/su.pport_page.php/moving-through-cancer/.
Light therapy [44,85,106,132]	Using a therapeutic light box is a known evidence-based approach to improve mood and regulate circadian rhythms. There is emerging evidence indicating benefits for sleep and fatigue in cancer patients.