Skip to main content
. Author manuscript; available in PMC: 2021 Sep 9.
Published in final edited form as: J Med Chem. 2020 Nov 16;63(22):13951–13972. doi: 10.1021/acs.jmedchem.0c01498

Scheme 1. Synthetic Routes of Compounds 12a–ca.

Scheme 1.

aReagents and conditions: (a) CF3COOH, Et3SiH, CH2Cl2, overnight, and 89%. (b) Et3N, EtOH, rt., overnight, and 63–67%. (c) 2-(3-Fluoro-5-(trifluoromethyl)phenyl)acetonitrile (9a), NaH, DMF, 0 °C to rt., 2 h, and 53–66%. (d) Con. HCl/AcOH/H2O, reflux, overnight, and 91–93%. (e) NH2CH2CH2OH, EDCI, DMAP, DMF, rt., overnight, and 73–83%.