Skip to main content
. Author manuscript; available in PMC: 2021 Sep 9.
Published in final edited form as: J Med Chem. 2020 Nov 16;63(22):13951–13972. doi: 10.1021/acs.jmedchem.0c01498

Table 6.

In Vivo Pharmacokinetic Parameters of Compound 12c in Ratsa

route AUC0-∞ (ng·h/mL) t1/2 (h) Cmax (ng/mL) CL (L/h/kg) Vss (L/kg) F (%)
PO 13,749 ± 2710 2.5 ± 0.2 3407 ± 179 l.5 ± 0.3 5.5 ± 1.16 76 ± 15
IV 9030 ± 1018 1.0 ± 0.1 6726 ± 727 1.1 ± 0.1 1.5 ± 0.2
a

AUC0-∞, area under the curve (t = 0 to 24 h); t1/2, terminal half-life; Cmax, maximum concentration of the drug in plasma; CL, plasma clearance; Vss, volume of distribution at steady state; F, absolute oral bioavailability. Experiments were studied in biological triplicates, and data values are shown as the mean ± SEM.