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Brain Permeability of Compound 12c in Ratsa
| route | time (h) | brain conc. (ng/g) | plasma conc. (ng/g) | brain/plasma ratio |
|---|---|---|---|---|
| IV | 0.25 | 1807 ± 198 | 6324 ± 271 | 0.28 ± 0.02 |
| 1 | 1006 ± 43 | 2589 ± 241 | 0.39 ± 0.02 |
Concentrations of compound 12c in the brain and plasma were determined at 0.25 and 1 h after a single dose of 10 mg/kg by IV. Experiments were studied in biological triplicates, and data values are shown as the mean ± SEM.
