Figure 10.

Cardiovascular function assessment in 4-mo-old male control and intrauterine growth-restricted (IUGR) offspring selected based on similar body weight at time of study from Sham-operated and reduced uterine perfusion pressure dams treated with vehicle or a soluble guanylate cyclase (sGC) stimulator (Riociguat 10 mg/kg/day). A: global longitudinal strain. B: stroke volume C: ejection fraction. D: cardiac output. Each data point represents 1 male offspring selected based on similar body weight at time of study from 4 litters; n = 4 Vehicle Control offspring; n = 4 Vehicle IUGR offspring; n = 4 sGC Control offspring; n = 4 sGC IUGR offspring. Scatter plots represent means ± SE. Two-way ANOVA with Tukey’s post hoc analysis was used for pairwise comparison. *P < 0.05, significant difference.