Table 1.

Echocardiogram measurements

	Sham	sGC Sham	RUPP	sGC RUPP	P Value
Heart rate, beats/min	290 ± 7	293 ± 5	284 ± 6	322 ± 11*,†	Interaction: P = 0.0328 sGC stimulator: P = 0.1501 IUGR: P = 0.0182
Fractional shortening, %	31 ± 1	32 ± 1	29 ± 1	27 ± 3	Interaction: P = 0.6496 sGC stimulator: P = 0.5993 IUGR: P = 0.0651
End-diastolic volume, µL	542 ± 6	534 ± 56	454 ± 51	518 ± 38	Interaction: P = 0.4146 sGC stimulator: P = 0.5220 IUGR: P = 0.2411
End-systolic volume, µL	224 ± 7	247 ± 37	226 ± 36	285 ± 28	Interaction: P = 0.5465 sGC stimulator: P = 0.1893 IUGR: P = 0.5121
End-diastolic left ventricular mass, mg	1,182 ± 37	1,160 ± 92	1,242 ± 70	1,351 ± 116	Interaction: P = 0.4506 sGC stimulator: P = 0.6116 IUGR: P = 0.1613
End-systolic left ventricular mass, mg	1,248 ± 7	1,285 ± 114	1,307 ± 84	1,420 ± 20	Interaction: P = 0.6990 sGC stimulator: P = 0.4477 IUGR: P = 0.3309

Values are means ± SE per group. Shown are echocardiogram measurements for heart rate and cardiovascular function assessment in 4-mo-old male control and intrauterine growth-restricted (IUGR) offspring from sham-operated and reduced uterine perfusion pressure (RUPP) dams treated with vehicle or a soluble guanylate cyclase (sGC) stimulator (Riociguat 10 mg/kg/day). Each value represents 1 male offspring selected based on similar body weight at time of study from 4 litters; n = 4 vehicle control offspring; n = 4 vehicle IUGR offspring; n = 4 sGC control offspring; n = 4 sGC IUGR offspring. Two-way ANOVA with Tukey’s post hoc analysis was used for pairwise comparison. *P < 0.05, significant difference between sham vs. sGC-treated RUPP. †P < 0.05, significant difference between sGC-treated sham vs. sGC-treated RUPP.