Table II.
Multivariable logistic regression of the risk of COVID-19 infection and subsequent mortality for patients treated with immunosuppressive biologics
| Variable | OR | 95% CI | P value |
|---|---|---|---|
| Risk of infection for all immunosuppressive biologics | |||
| Biologic use | 0.88 | 0.71-1.09 | .25 |
| Age group (years) | |||
| 18-44 | ref∗ | ref∗ | ref∗ |
| 45-64 | 0.92 | 0.79-1.07 | .28 |
| 65-74 | 0.67 | 0.53-0.85 | .001 |
| ≥75 | 1.22 | 0.96-1.56 | .11 |
| Sex, female | 0.95 | 0.85-1.07 | .43 |
| Race and ethnicity | |||
| White non-Hispanic | ref∗ | ref∗ | ref∗ |
| Asian or Pacific Islander non-Hispanic | 0.36 | 0.21-0.62 | <.001 |
| Black non-Hispanic | 2.10 | 1.73-2.56 | <.001 |
| Other non-Hispanic | 1.36 | 1.04-1.79 | .02 |
| Hispanic | 1.39 | 0.99-1.94 | .06 |
| Unknown | 0.28 | 0.13-0.58 | .001 |
| CCI grade | |||
| Mild (1-2) | ref∗ | ref∗ | ref∗ |
| Moderate (3-4) | 1.32 | 1.11-1.56 | <.01 |
| Severe (≥5) | 1.88 | 1.56-2.26 | <.001 |
| COVID-19 town or county positivity rate | 1.24 | 1.19-1.29 | <.001 |
| Median income in $1,000s | 0.98 | 0.95-1.00 | .06 |
| Risk of infection by immunosuppressive biologic class | |||
| Class | |||
| B-cell activating factor inhibitor | 0 | 0.00-Inf | .98 |
| CD20-directed cytolytic antibody | 1.16 | 0.73-1.83 | .53 |
| Integrin receptor antagonist | 1.27 | 0.61-2.68 | .52 |
| Interleukin-1 receptor antagonist | 2.23 | 0.31-15.82 | .42 |
| Interleukin-4A receptor antagonist | 0.38 | 0.12-1.18 | .10 |
| Interleukin-6 receptor antagonist | 1.35 | 0.60-3.02 | .47 |
| Interleukin-12/23 receptor antagonist | 0.88 | 0.33-2.34 | .79 |
| Interleukin-17A receptor antagonist | 1.75 | 0.83-3.69 | .14 |
| Interleukin-23 antagonist | 1.60 | 0.23-11.40 | .64 |
| Selective T-cell costimulation modulator | 1.63 | 0.61-4.36 | .33 |
| Tumor necrosis factor inhibitor | 0.69 | 0.48-0.98 | .04 |
| Risk of subsequent all-cause mortality for all immunosuppressive biologics | |||
| Biologic use | 1.13 | 0.57-2.76 | .57 |
| Age | 1.06 | 1.04-1.09 | <.001 |
| Sex, female | 0.53 | 0.34-0.83 | <.01 |
| CCI grade | |||
| Mild (1-2) | ref∗ | ref∗ | ref∗ |
| Moderate (3-4) | 2.12 | 0.69-6.51 | .19 |
| Severe (≥5) | 2.96 | 0.99-8.86 | .05 |
| Median income in $1000s | 0.90 | 0.80-1.00 | .06 |
| COVID-19 town or county positivity rate | 0.93 | 0.78-1.11 | .45 |
CCI, Charlson Comorbidity Index; OR, odds ratio; ref, reference.
∗
Reference variable. P values <0.05 appear in bold.