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. 2021 Sep 10;24(10):103115. doi: 10.1016/j.isci.2021.103115

Figure 4.

Figure 4

COVID-19 driven reprogramming of platelets leads to drastically altered expression of genes associated with platelet adhesion, activation, coagulation and thrombosis

(A and B) Uniform Manifold Approximation and Projections (UMAPs) show distributions of sub-clusters (A) and COVID-19 conditions (B) of platelets after the integration of PBMC datasets.

(C) Severity-associated coagulation genes were selected and shown on the heatmap, with disease and sub-cluster specific gene patterns identified and labeled. Their functional associations with coagulation pathways were retrieved from ToppGene and shown on the right.

(D) Functional and phenotypical associations of coagulation-association genes in each gene pattern from (C). Associations were retrieved from ToppGene enrichment output and eight enrichment categories are represented by rectangles with unique colors. Thicken colored edges represent associations of highlighted functions, such as cell-matrix binding and regulation of coagulation. Hypothesized pathway cascade that potentially drives thromboembolism in COVID-19 patients is drawn in red dotted line. See also Figures S12, S13 and Table S4.