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APN release from lung explants. (A) Time-course of APN release from nonstimulated human lung explants cultured for 2, 4 and 24 h. Data are reported as the mean ± SEM of 5–11 independent experiments (***: p < 0.001). (B) Relationship between the APN production from unstimulated human lung explants after 24 h incubation assessed as the concentration in the supernantants and the donor’s BMI (n = 30). Spearman’s correlation coefficient r = -0.48; p = 0.008.
