FIGURE 7.

Inhibitory effects of APN and AdipoRon on the IL-4-induced chemokine release by human LMs. Macrophages were incubated in the absence or presence of APN (3, 10 or 30 µg ml⁻¹) or AdipoRon (5, 10, 25 or 50 µM) before being stimulated with IL-4 (10 ng ml⁻¹) for 24 h. Data are expressed as a percentage with respect to IL-4-induced production. Results are shown as the mean ± SEM of 6–12 different experiments. Asterisks indicate significant effects with respect to IL-4 alone (*:p < 0.05; **: p < 0.01; ***: p < 0.001).