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. 2021 Sep 1;2021:5387799. doi: 10.1155/2021/5387799

Figure 5.

Figure 5

Effect of melatonin on NLRP3 inflammasome-mediated pyroptosis through inhibition of the TLR4/NF-κB signaling pathway. (a) LPS (1 μg/mL) blocked the effect of melatonin on H9C2 cardiomyocyte cell death. Live cells were stained with calcein-AM (green), and dead cells were stained with EthD-III (red). Scale bar, 40 μm. (b–f) Representative images and statistical analysis of GSDMD-N (b), NLRP3 (c), and cl.casp-1 (d), mature IL-1β (e), and mature IL-18 (f) data from different groups. ∗P < 0.05 vs. ctl, #P < 0.05 vs. hypoxia, $P < 0.05 vs. MLT. Number of trials = 3. MLT: melatonin.