Table 4.

Effects of metabolic syndrome (MetS) on live birth rates and pregnancy complications by ovulation induction medication in PPCOSII

Live Births
	Letrozole	P*	Clomiphene Citrate	P*	P**
BMI 16.7-67.5		0.06		<.01
No MetS	76/248(30.7%)		57/245(23.3%)		0.06
MetS	27/125(21.6%)		15/129(11.6%)		0.03
Obese BMI >25 kg/m2	81/314(25.8%)	0.17	51/313(16.3%)	0.03	<0.01
No MetS	54/189 (28.6%)		37/185 (20.0%)		0.06
MetS	27/125 (21.6%)		14/128 (10.9%)		0.02
BMI 25-35 kg/m2	36/128(28.1%)	0.14	27/123 (22.0%)	0.03	0.26
No MetS	29/91 (31.8%)		23/83 (27.7%)		0.55
MetS	7/37 (18.9%)		4/40 (10.0%)		0.34
BMI > 35 kg/m2	45/186(24.2%)	0.66	24/190(12.6%)	0.63	<0.01
No MetS	25/98 (25.5%)		14/102 (13.7%)		0.04
MetS	20/88 (22.7%)		10/88 (11.4%)		0.05
Pregnancy Complication
	Letrozole	P*	Clomiphene Citrate	P*	P**
All BMI	35/72(48.6%)	0.01	50/103(48.5%)	0.87	0.99
No MetS	31/76(40.8%)		28/57(49.1%)		0.33
MetS	19/27(70.4%)		7/15(46.7%)		0.19
Obese BMI >25 kg/m2	44/81(54.3%)	0.04	27/51 (52.9%)	0.16	0.88
No MetS	25/54(46.3%)		20/37 (54.1%)		0.47
MetS	19/27(70.4% )		7/14 (50.0%)		0.20
BMI 25-35 kg/m2	13/36(36.1%)	0.20	14/27 (51.8%)	0.33	0.21
No MetS	9/29(31.0%)		13/23 (56.5%)		0.09
MetS	4/7(57.1%)		1/ 4 (25.0%)		0.55
BMI > 35 kg/m2	31/45(68.9%)	0.43	13/24(54.2%)	0.77	0.23
No MetS	16/25(64.0%)		7/14(50.0%)		0.40
MetS	15/20(75.0%)		6/10(60.0%)		0.43

Chi-Square or Fisher’s Exact test.

^*P-value within medication for MetS.(categorical)

^**P-value between medications.

Pregnancy complications are limited to those with a live birth and refer to having had a complication during pregnancy (any). This includes preterm labor, preeclampsia, hyperemesis, gestational diabetes, IUGR, incompetent cervix, premature rupture of the membranes, and/or other