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. 2021 Jun 19;271(7):1231–1243. doi: 10.1007/s00406-021-01280-w

Table 2.

Study flow chart

Study period
Pre-Treatment Treatment Follow-up
Week 0 1 2 3 4 5 6 10 18
Visit Screening Baseline V1-V5 V6-V10 V10 V11-V15 V16-V20 V20 V21-V25 V26-V30 V30 V31 V32
Informed consent X
Sociodemography X
Pregnancy test1 X
Physical/neurological examination X
Concomitant treatment2 X X X X X X X
SCID-5-PD X
ATHF-SF X
MADRS (item 10 only) X
HDRS-17 X X X X X X
Randomization X
MADRS (complete) X X X X X X
BDI-II X X X X X X
CGI X X X X X X
WHO-5 X X X X
WPAI X X X
THINC-it® (test of cognition) X X X
CTQ X
EHI X
MRI3 X
Genetics3 X X X
Determination of resting motor threshold4 X
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Safety check graphic file with name 406_2021_1280_Figg_HTML.gif graphic file with name 406_2021_1280_Figh_HTML.gif graphic file with name 406_2021_1280_Figi_HTML.gif graphic file with name 406_2021_1280_Figj_HTML.gif graphic file with name 406_2021_1280_Figk_HTML.gif graphic file with name 406_2021_1280_Figl_HTML.gif

1Pregnancy test is only necessary for women in child-bearing age; if a blood sample is taken as part of the clinical routine, it is advisable to check a possible pregnancy with a blood test. Otherwise, a urine test can be used to avoid unnecessary risks

2Concomitant medication and/or any type of psychotherapy will be documented for each patient for his/her entire participation period

3MRI and Genetics are not part of the standard protocol but belong to two satellite projects

4Alternatively, the threshold can also be determined directly before the first stimulation, i.e. in visit 1