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. 2021 Apr 19;109(4):383–392. doi: 10.1007/s00223-021-00848-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Serum total (ALP, a) and bone (BAP, b) alkaline phosphatase levels over time in all patients with Paget’s disease of bone before and after the first infusion of zoledronate. Patients repeating treatment were subsequently excluded from the analysis. Data are represented as mean ± standard error of the mean. *p < 0.05 vs basal values. n number of patients assessed at each time point, nr number of patients with ALP or BAP within reference range at each time point