Table 2.
Univariate and multivariable logistic regressions to evaluate factors associated with occult disease in all patients. Pseudo R-squared = 0.05 for multivariable regression.
| Univariate | Multivariable | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Independent variables | Odds ratio | 95% CI | P-value | Odds ratio | 95% CI | P-value |
|
| ||||||
| Age at transplant | 1.00 | 0.98–1.02 | 0.99 | -- | -- | -- |
|
| ||||||
| Female gender | 0.77 | 0.52–1.12 | 0.18 | -- | -- | -- |
|
| ||||||
| Etiology of liver disease | -- | -- | -- | |||
| Hepatitis C | 0.76 | 0.54–1.06 | 0.11 | |||
| Hepatitis B | 0.86 | 0.48–1.53 | 0.60 | |||
| Alcohol | 1.45 | 0.80–2.64 | 0.22 | |||
|
| ||||||
| Biochemical MELD score at time of transplant | 1.05 | 1.03–1.07 | <0.001 | 1.02 | 1.00–1.05 | 0.048 |
|
| ||||||
| Most recent AFP prior to transplant | 1.00 | 1.00–1.00 | 0.40 | -- | -- | -- |
|
| ||||||
| Days on waitlist | 1.00 | 1.00–1.00 | 0.93 | -- | -- | -- |
|
| ||||||
| Received pre-transplant treatment | ||||||
| TACE | 0.57 | 0.42–0.78 | <0.001 | -- | -- | |
| RFA | 0.78 | 0.50–1.21 | 0.27 | -- | ||
| Resection | 1.26 | 0.46–3.46 | 0.65 | |||
| Radioembolization | 0.39 | 0.10–1.47 | 0.16 | |||
| Percutaneous ethanol injection | 2.57 | 0.24–27.12 | 0.43 | |||
| Number of treatments | 0.79 | 0.67–0.92 | 0.003 | |||
|
| ||||||
| Most recent pre-transplant imaging | ||||||
| MRI | Ref. | -- | -- | Ref. | -- | -- |
| CT | 1.98 | 1.18–3.31 | 0.01 | 1.82 | 1.07–3.11 | 0.03 |
| Ultrasound | 6.72 | 1.93–23.31 | 0.003 | 4.15 | 1.11–15.48 | 0.03 |
|
| ||||||
| Findings on preoperative imaging | ||||||
| PVT | 2.02 | 1.22–3.39 | 0.007 | 1.97 | 1.14–3.40 | 0.02 |
| TIPS | 5.22 | 2.37–11.49 | <0.001 | 4.16 | 1.84–9.40 | <0.001 |
| Indeterminate lesion(s) | 1.47 | 0.87–1.48 | 0.02 | 1.50 | 1.02–2.18 | 0.04 |
|
| ||||||
| Days from imaging to transplant | 1.00 | 1.00–1.00 | 0.16 | -- | -- | -- |
AFP = alpha-fetoprotein. CI = confidence interval. CT = computerized tomography. MELD = Model for End-Stage Liver Disease. MRI = magnetic resonance imaging. PVT = portal venous thrombus. RFA = radiofrequency ablation. TACE = trans-arterial chemoembolization. TIPS = transjugular intrahepatic portosystemic shunt.