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. Author manuscript; available in PMC: 2022 Sep 5.
Published in final edited form as: Int J Pharm. 2021 Jul 10;606:120877. doi: 10.1016/j.ijpharm.2021.120877

Table 5.

Predicted and observed responses for the optimized formulation and evaluation of the sensitivity of the design space

Response Predicted value Observed % Error*
Software suggested solution for optimized formulation (RVT-NLCs)
Particle size (nm) 102.37 104.47±4.35 2.05
Polydispersity index 0.19 0.19±0.02 3.61
Zetapotential (mV) −10.51 −9.81±0.75 6.66
Entrapment efficiency (%) 78.91 77.57±1.06 1.70
Flagged region-1
Particle size (nm) 79.20 79.65±4.13 0.57
Polydispersity index 0.18 0.18±0.09 0.55
Zeta potential (mV) −10.37 −10.39±2.99 0.19
Entrapment efficiency (%) 75.61 74.63±1.18 1.30
Flagged region-2
Particle size (nm) 83.16 87.57±3.82 5.30
Polydispersity index 0.21 0.20±0.01 5.31
Zetapotential (mV) −10.11 −9.41±3.98 6.92
Entrapment efficiency (%) 70.02 69.54±0.52 0.68
Flagged region-3
Particle size (nm) 159.76 156.90±6.70 1.79
Polydispersity index 0.25 0.24±0.03 2.02
Zetapotential (mV) −9.95 −10.27±1.31 3.22
Entrapment efficiency (%) 79.94 79.25±1.40 0.86
*

% Error = (Predicted results – observed results)/Predicted results ×100