Table 2.

Late-onset kidney failure among survivors of childhood cancer, overall and by primary cancer diagnosis

	35-year cumulative incidence (95% confidence interval)	Rate ratio* (95% confidence interval)	P
Siblings	0.2 (0.1 – 0.4)	Ref.	-
Survivors (overall)	1.7 (1.4 – 1.9)	4.9 (2.6 – 9.2)	<0.001
Survivors by diagnosis
Central nervous system tumor	0.6 (0.3 – 0.8)	Ref.	-
ALL	1.2 (0.9 – 1.5)	1.5 (0.8 – 2.7)	0.22
AML	2.0 (1.0 – 3.0)	2.2 (1.0 – 5.2)	0.060
Hodgkin lymphoma	0.9 (0.5 – 1.4)	1.2 (0.6 – 2.4)	0.64
Non-Hodgkin lymphoma	3.6 (2.2 – 4.9)	2.0 (1.0 – 3.8)	0.043
Wilms tumor	3.8 (2.8 – 4.8)	4.7 (2.6 – 8.4)	<0.001
Neuroblastoma	2.1 (1.1 – 3.2)	2.5 (1.2 – 4.9)	0.010
Soft tissue sarcoma	1.0 (0.3 – 1.6)	1.2 (0.6 – 2.7)	0.63
Ewing sarcoma	1.7 (0.7 – 2.8)	2.5 (1.0 – 5.9)	0.047
Osteosarcoma	2.7 (1.3 – 4.1)	2.6 (1.3 – 5.4)	0.008

^*adjusted for attained age, sex and race/ethnicity