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. Author manuscript; available in PMC: 2022 Sep 5.
Published in final edited form as: Int J Pharm. 2021 Jul 14;606:120887. doi: 10.1016/j.ijpharm.2021.120887

Table 3:

Percent accuracy, precision (relative standard deviation) and paired two tailed t-test (p-value) for noninvasive volume measures for suprachoroidal, subretinal, and intravitreal implants. P > 0.05 indicates no significant differences between the two types of measurements. Data are presented as mean SD for n=4–5 eyes. Key: SC- Suprachoroidal, SR- Subretinal, and IVT- Intravitreal, NE-Not estimated.

Accuracy (%), precision (%) and p-value for volume estimation compared to blade micrometer values
Accuracy (%) Precision (%) p-value
SC SR IVT SC SR IVT SC SR IVT
Metal implant
0.65×6.35 mm cSLO image 90±26 46±10 61±7 29 22 12 0.490 0.002 0.002
OCT image-Integrated bleb area over length 157±2 186±20 NE 2 11 NE 0.000 0.003
cSLO image and thickness map 79±7 105±23 NE 9 22 NE 0.009 0.680
0.57×6.35 mm cSLO image 93±25 70±18 65±11 26 25 17 0.624 0.043 0.008
OCT image-Integrated bleb area over length 154±69 200±44 NE 45 22 NE 0.217 0.020
cSLO image and thickness map 63±30 101±28 NE 47 27 NE 0.089 0.937
0.23×9.51 mm cSLO image 152±57 116±8 105±48 38 7 46 0.165 0.027 0.847
OCT image-Integrated bleb area over length 552±313 556±127 NE 57 23 NE 0.065 0.005
cSLO image and thickness map 111±56 279±53 NE 51 19 NE 0.731 0.007
1.27×6.45 mm cSLO image 65±29 62±6 102±14 45 10 14 0.097 0.001 0.800
OCT image-Integrated bleb area over length 124±48 252±37 NE 57 23 NE 0.394 0.004
cSLO image and thickness map 61±34 104±8 NE 51 19 NE 0.108 0.381
Polymeric implant
~0.4×2 mm cSLO image 42±31 95±33 94±14 89 41 18 0.045 0.790 0.509
OCT image-Integrated bleb area over length 117±54 165±79 NE 55 46 NE 0.660 0.125
cSLO image and thickness map 32±17 66±26 NE 61 38 NE 0.014 0.042
~0.4×4 mm cSLO image 55±32 104±17 81±7 55 16 11 0.080 0.789 0.003
OCT image-Integrated bleb area over length 135±11 175±33 NE 10 38 NE 0.007 0.044
cSLO image and thickness map 45±10 91±26 NE 27 45 NE 0.001 0.676
~0.4×6 mm cSLO image 104±42 85±15 67±6 28 30 8 0.977 0.111 0.002
OCT image-Integrated bleb area over length 183±58 181±30 NE 23 27 NE 0.044 0.014
cSLO image and thickness map 53±8 89±19 NE 21 35 NE 0.003 0.280