Table 3.
Peak Subjective Effects of Oral Minocycline in Combination with Oral Oxycodone (N=12 unless otherwise indicated). Values represent means (standard errors of the mean) from peak comparisons.
| Oxycodone (0 mg) | Oxycodone (40 mg) | ||||
|---|---|---|---|---|---|
| Minocycline Dose (mg, oral) | |||||
| 0 mg | 200 mg | 0 mg | 100 mg | 200 mg | |
| VAS Subjective Efects | |||||
| Bad effect | 11.9 (8.4) | 8.4 (5.1) | 35.2 (11.0)a*b* | 33.8 (11.0)a*b* | 31.1 (9.9)cb* |
| Good effect | 10.2 (6.2) | 11.8 (4.8) | 59.3 (9.3)a*b* | 49.3 (10.1)a*b* | 41.4 (10.1)a*b* |
| High | 15.6 (7.5) | 8.4 (3.1) | 65.8 (8.3)a*b* | 66.3 (7.9)a*b* | 60.8 (7.2)a*b* |
| Liking | 12.1 (7.9) | 17.1 (6.1) | 54.8 (10.3)a*b* | 42.7 (10.5)a*d | 39.3 (9.6)a*d |
| Potent | 11.6 (6.6) | 13.2 (4.7) | 60.3 (11.1)a*b* | 59.3 (11.0)a*b* | 54.9 (9.7)a*b* |
| VAS Craving Effects | |||||
| Want alcohol (N=10) | 12.3 (9.8) | 3.0 (1.6) | 19.9 (9.7) | 15.4 (7.4) | 12.7 (8.6) |
| Want cocaine (N=3) | 24.3 (15.6) | 5.0 (3.2) | 31.0 (14.1) | 13.3 (7.3) | 24.0 (18.2) |
| Want opioid (N=12) | 9.4 (6.4) | 6.3 (4.4) e | 15.3 (9.2) | 9.2 (7.7) | 8.8 (8.3) |
| Want tobacco (N=5) | 63.0 (17.9) | 27.8 (17.8)c | 41.2 (22.9) | 48.6 (17.0) | 38.8 (21.4) |
| VAS Cognitive Effects | |||||
| Alert | 49.3 (9.4) | 43.5 (7.5) | 43.0 (7.1) | 54.7 (5.7) | 41.2 (7.0) |
| Anxious | 18.9 (7.7) | 11.2 (7.1) | 7.1 (3.6)c | 19.7 (8.1)e | 10.2 (3.3) |
| Depressed | 11.9 (5.9) | 5.3 (3.0) | 11.1 (7.0) | 18.8 (10.3)d | 16.4 (8.7)d |
| Irritable | 21.0 (9.5) | 15.5 (5.4) | 23.8 (9.9) | 24.8 (10.0) | 18.9 (5.4) |
| Sedated | 18.7 (9.5) | 16.8 (8.7) | 61.0 (9.3)a*b* | 64.0 (8.8)a*b* | 57.9 (8.5)a*b* |
| Stimulated | 11.8 (4.6) | 14.2 (5.2) | 33.1 (9.5)cd | 24.5 (6.2) | 31.8 (9.4)cd |
| CPT Analgesic Effects | |||||
| MPQ Sum | 34.6 (4.0) | 34.4 (4.0) | 33.4 (4.3) | 34.9 (4.0) | 31.9 (3.4) |
| How bothersome | 8.6 (0.6) | 8.8 (0.6) | 8.0 (0.8) | 9.1 (0.5) | 7.7 (0.9)f |
| Pain Intensity | 8.6 (0.6) | 8.8 (0.6) | 8.2 (0.8) | 9.1 (0.4) | 7.8 (0.9)f |
| Latency to feel pain | 43.6 (18.6) | 53.0 (19.4) | 66.1 (20.5) | 76.8 (19.4)c | 56.8 (18.1) |
| Latency to withdraw | 60.5 (20.5) | 61.5 (21.0) | 89.5 (21.1)cd | 93.8 (19.8)a*b* | 89.1 (21.0)cd |
a*
represents significant difference (p<0.01) from oxycodone 0 mg + minocycline 0 mg.
b*
represents significant difference (p<0.01) from oxycodone 0 mg + minocycline 200 mg.
c
represents difference (p<0.05) from oxycodone 0 mg + minocycline 0 mg.
d
represents difference (p<0.05) from oxycodone 0 mg + minocycline 200 mg.
e
represents difference (p<0.05) from oxycodone 40 mg + minocycline 0 mg.
f
represents difference (p<0.05) from oxycodone 40 mg + minocycline 100 mg.
VAS = Visual Analog Scale, CPT = Cold Pressor Test