Table 4.
Select performance measure for the Divided Attention Task (DAT) and Digit-Symbol Substitution Task (DSST) as a function of oral oxycodone and minocycline dose. Values represent the mean performance post-drug (standard error) from peak comparisons.
| Oxycodone (0 mg) | Oxycodone (40 mg) | ||||
|---|---|---|---|---|---|
| Minocycline Dose (mg, oral) | |||||
| 0 mg | 200 mg | 0 mg | 100 mg | 200 mg | |
| DAT | |||||
| Number of False Alarms | 3.2 (1.1) | 2.8 (0.9) | 3.2 (0.9) | 4.9 (1.5) | 5.2 (1.1)d |
| Number of Hits | 18.8 (0.4) | 19.1 (0.3) | 18.8 (0.5) | 19.3 (0.3) | 18.9 (0.5) |
| Number of Misses | 0.8 (0.3) | 0.9 (0.4) | 1.5 (0.4) | 1.0 (0.3) | 1.8 (0.9) |
| Maximum Speed | 6.4 (0.8) | 6.0 (0.5) | 4.6 (0.4)a*d | 3.7 (0.6)a*b* | 4.3 (0.5)a*b* |
| Tracking Distance (m) | 15.6 (3.0) | 14.4 (1.7) | 21.4 (2.2)d | 20.5 (2.9) | 25.3 (1.9)a*b* |
| DSST | |||||
| Total Number Attempted | 76.2 (3.1)f | 73.8 (3.4) | 75.4 (5.4) | 67.1 (2.6)c | 68.4 (3.9) |
| Total Number Correct | 72.3 (5.1)f | 70.2 (3.6) | 73.0 (5.0)f | 62.0 (4.3)ce | 64.7 (4.8) |
represents significant difference (p<0.01) from oxycodone 0 mg + minocycline 0 mg.
represents significant difference (p<0.01) from oxycodone 0 mg + minocycline 200 mg.
represents difference (p<0.05) from oxycodone 0 mg + minocycline 0 mg.
represents difference (p<0.05) from oxycodone 0 mg + minocycline 200 mg.
represents difference (p<0.05) from oxycodone 40 mg + minocycline 0 mg.
represents difference (p<0.05) from oxycodone 40 mg + minocycline 100 mg.
DAT = Divided attention task, DSST= Digit symbol substitution task