Table 3.
Concentrations of primary aromatic amines measured in real urine samples by following the method developed in this study.
| Sample type | Aromatic amines (ng/mL) | Tobacco components | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aniline | p-anisidine | o-anisidine | p-TD |
o/m- TD |
4-CA | 3-CA | 3,4- DCA |
4,4'- MDA |
2,4 - DAT |
Nicotine (ng/mL) |
Cotinine (ng/mL) |
||
| Urine samples from healthy adults (n =20) | max | 1.50 | 1.01 | 0.21 | 0.08 | 0.63 | 0.28 | 1.01 | 0.72 | 0.42 | 9.10 | 446 | 1890 |
| mean | 0.65 | 0.13 | 0.06 | 0.03 | 0.16 | 0.10 | 0.29 | 0.20 | 0.13 | 2.11 | 69 | 245 | |
| median | 0.53 | 0.01 | 0.04 | 0.03 | 0.08 | 0.07 | 0.27 | 0.11 | 0.08 | 0.47 | 0.38 | 0.43 | |
| Known smoker’s urine 1 | 2.74 | 0.37 | <LOD | 0.06 | 2.26 | 0.11 | 0.05 | <LOD | <LOD | <LOD | 807 | 127 | |
| Known smoker’s urine 2 | 3.47 | 0.39 | <LOD | 0.07 | 2.32 | 0.11 | 0.04 | <LOD | <LOD | <LOD | 720 | 123 | |
| Known smoker’s urine 3 | 1.16 | 0.83 | <LOD | 0.10 | 4.41 | 0.82 | 9.16 | 1.12 | 0.26 | <LOD | 1210 | 357 | |
| NIST SRM 3672* | 3.32 | 0.44 | <LOD | 0.27 | 4.57 | 0.16 | 0.26 | <LOD | 0.46 | <LOD | 725 | 1120 | |
*
values are average of triplicate analysis.