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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Exp Neurol. 2021 Jul 24;345:113815. doi: 10.1016/j.expneurol.2021.113815

Figure 1. RNA-Sequencing identifies four commonly down-regulated ALS genes.

Figure 1.

ALS patient iPSCs were collected for RNA sequencing after 14 days of terminal differentiation. (A) Principal Component Analysis (PCA) plot showing the clustering of control lines compared to the variation in ALS lines. (B) Compared to healthy control lines, only four genes were commonly down-regulated across all ALS lines: BET1L, DCX, GPC3, and HNRNPK. (C-F) Interactomes for each of the genes of interest.