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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):13038–13053. doi: 10.1021/acs.jmedchem.1c01130

Figure 1.

Figure 1.

Binding affinity of B4-27 to KRas. (a) HTRF assay showing inhibition of the interaction between KRasG12V-GppNHp (50 nM) and CRAF RBD (50 nM) by B4-27. (b) Binding of B4-27FAM (100 nM) to KRasG12V loaded with GTPγS, GppNHp, or GDP as monitored by FP. Data reported are presented as mean ± SD of n ≥ 3 independent experiments.