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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Biomed Pharmacother. 2021 Jul 15;141:111912. doi: 10.1016/j.biopha.2021.111912

Figure 4. Treprostinil reduces mitochondrial oxidative injury and preserves renal mtDNA copy number.

Figure 4.

(A) CAT activity, (B) SOD activity, (C) GSH content, and (D) protein carbonyl content in the kidney compared between control, sham, IRI-placebo and IRI-treprostinil groups at 1-, 6-, 24- and 48-hours post-reperfusion. Renal mRNA expression levels of (E) Nqo1, (F) Gclc. Data are represented as mean ± SD; *p<0.05, **p<0.01, ***p<0.001 vs. sham, †p<0.05, ††p<0.01, †††p<0.001 vs. placebo (n = 4–6/group). Two-way ANOVA, Tukey’s multiple comparison test. CAT: catalase; SOD: superoxide dismutase; GSH: glutathione; Nqo1: NAD(P)H dehydrogenase (quinone 1); Gclc: Glutamate-cysteine ligase catalytic subunit.