Table 3.
Performance of the predictive models for preeclampsia, preeclampsia with delivery < 37 weeks and preeclampsia with delivery ≥ 37 weeks at different gestational ages in the in the study population of 58 899 nulliparous women.
| Gestational age of prediction† (weeks) | Preeclampsia | Preeclampsia with delivery < 37 weeks’ gestation | Preeclampsia with delivery ≥ 37 weeks’ gestation* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC‡ | (95% CI) | Sensitivity for 10% FPR§ | (95% CI) | AUC‡ | (95% CI) | Sensitivity for 10% FPR§ | (95% CI) | AUC‡ | (95% CI) | Sensitivity for 10% FPR§ | (95% CI) | |
| 24 | 0.69 | (0.66–0.71) | 29.0 | (25.5–34.0) | 0.73 | (0.68–0.79) | 37.2 | (26.5–48.9) | 0.65 | (0.63–0.68) | 25.2 | (20.9–29.9) |
| 28 | 0.70 | (0.69–0.72) | 30.2 | (29.5–33.6) | 0.78 | (0.76–0.81) | 43.0 | (37.2–48.9) | 0.67 | (0.66–0.69) | 25.5 | (23.5–27.6) |
| 32 | 0.73 | (0.72–0.75) | 35.4 | (33.3–37.5) | 0.85 | (0.82–0.87) | 59.7 | (52.9–66.3) | 0.71 | (0.69–0.72) | 29.6 | (27.4–31.7) |
| 34 | 0.77 | (0.75–0.78) | 41.0 | (38.8–43.3) | 0.87 | (0.84–0.90) | 66.4 | (57.6–74.4) | 0.75 | (0.73–0.76) | 37.5 | (35.2–39.8) |
| 36 | 0.80 | (0.78–0.81) | 46.4 | (43.9–48.8) | 0.84 | (0.77–0.92) | 50.0 | (29.1–70.9) | 0.79 | (0.78–0.80) | 45.0 | (42.6–47.5) |
*Diagnosis of preeclampsia at any gestational length with delivery ≥ 37 weeks.
†The model is composed of the predictive variables collected at first antenatal visit, the time-varying predictors plasma glucose and proteinuria, and the u-scores of level, trend and curvature for each of the time-varying predictors systolic and diastolic blood pressure, haemoglobin, maternal weigh and symphysis fundal height up until the gestational week of prediction (24, 28, 32, 34 and 36).
‡AUC: Area under receiver operating characteristic curve.
§FPR: False positive rate.