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. 2021 Sep 9;11:17919. doi: 10.1038/s41598-021-97482-2

Figure 1.

Figure 1

EGFL7 levels in non-pregnant women, healthy pregnant women, and pregnant women affected by IUGR, Early PE and Late PE. (A) Mean (± SE) levels of Epidermal Growth Factor-like Domain 7 (EGFL7) in plasma of non-pregnant women (NP), healthy pregnant women (Controls), IUGR-, Early PE- (e-PE) and Late PE- (l-PE) affected pregnant women throughout pregnancy as measured by ELISA. Data were compared using the two-sample t-test between two samples (p < 0.001 for e-PE vs. CTRL and IUGR at GA 22–25; p = 0.05 for e-PE vs. CTRL and IUGR at GA 26–30; p = 0.045 for e-PE vs. IUGR at GA 31–34; p = 0.01 for l-PE vs. CTRL) or ANOVA test among the three studied groups (p < 0.001 at GA 22–25 and p = 0.036 at GA 35–40). Statistically significant difference within gestational interval is reported. SigmaPlot 12.0 and GraphPad Prism 7 were used for statistical analysis. (B) Real-time PCR analysis for EGFL7 gene expression levels in placental samples obtained from Controls, IUGR- and l-PE- affected pregnant women at GA 35–40. Data were represented as mean (± SE). ANOVA test with post-hoc Bonferroni correction was used for statistical analysis (SigmaPlot 12.0). Differences were considered significant at p < 0.05.