Table 1.
Effects of QTN on FCA-induced alterations in body weight, change in joint diameter, change in paw volume, paw withdrawal latency, and paw withdrawal threshold (Von-Frey hair and paw pressure test).
| Treatment | AUC (Body weight (gm)) | AUC (change in joint diameter (mm)) | AUC (change in Paw volume (mL)) | AUC (Paw withdrawal latency (sec)) | AUC (Paw withdrawal threshold (g)) | AUC (Paw withdrawal threshold (g)) |
|---|---|---|---|---|---|---|
| Normal | 6299.00 ± 56.77 | 0.00 ± 0.00 | 0.18 ± 0.05 | 242.50 ± 6.92 | 1803.00 ± 41.74 | 8315.00 ± 72.92 |
| AIA Control | 5468.00 ± 37.06# | 87.06 ± 0.44# | 91.84 ± 1.62# | 120.60 ± 7.28# | 791.70 ± 24.85# | 4884.00 ± 130.20# |
| LF (10) | 5773.00 ± 96.24*,$ | 71.37 ± 0.99*,$ | 70.64 ± 0.84*,$ | 154.60 ± 7.94*,$ | 1037.00 ± 23.53*,$ | 5978.00 ± 160.60*,$ |
| QTN (5) | 5552.00 ± 103.6 | 86.18 ± 1.02 | 90.72 ± 0.58 | 127.80 ± 8.55 | 832.60 ± 12.94 | 5110.00 ± 106.30 |
| QTN (10) | 5681.00 ± 75.02*,$ | 79.64 ± 1.06*,$ | 81.50 ± 0.62*,$ | 142.90 ± 9.78*,$ | 897.20 ± 18.42*,$ | 5503.00 ± 45.96*,$ |
| QTN (20) | 5771.00 ± 72.76*,$ | 71.74 ± 0.85*,$ | 70.33 ± 0.96*,$ | 156.40 ± 8.66*,$ | 1034.00 ± 26.61*,$ | 5924.00 ± 91.91*,$ |
Values in parentheses indicate a dose in mg/kg (n = 6). Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. For comparison with AIA-control group: *p < 0.05, comparison with normal group: #p < 0.05 and comparison with one another: $p < 0.05. AIA adjuvant-induced arthritis, LF leflunomide, QTN 3,5,7,3′,4′-pentahydroxy flavone, AUC area under curve.