Table 2.
Effects of QTN on FCA-induced alterations in serum AST, ALT, ALP, albumin, CRP, and rheumatoid factor levels.
| Treatment | AST (U/mL) | ALT (U/mL) | Alkaline phosphatase (U/L) | Albumin (g/dl) | CRP (mg/L) | Rheumatoid factor (IU/mL) |
|---|---|---|---|---|---|---|
| Normal | 39.95 ± 3.02 | 33.78 ± 1.83 | 69.24 ± 5.42 | 6.52 ± 0.38 | 0.99 ± 0.04 | 0.00 ± 0.00 |
| AIA Control | 122.90 ± 2.84# | 165.80 ± 7.45# | 435.00 ± 11.81# | 2.00 ± 0.22# | 7.65 ± 0.34# | 60.25 ± 1.55# |
| LF (10) | 59.56 ± 3.74*,$ | 51.11 ± 5.14*,$ | 136.7 ± 5.59*,$ | 6.25 ± 0.31*,$ | 2.60 ± 0.24*,$ | 38.58 ± 1.47*,$ |
| QTN (5) | 118.70 ± 4.26 | 146.60 ± 3.80 | 423.20 ± 6.50 | 2.25 ± 0.26 | 7.02 ± 0.18 | 56.96 ± 1.61 |
| QTN (10) | 88.02 ± 3.71*,$ | 90.45 ± 3.86*,$ | 276.40 ± 12.82*,$ | 4.05 ± 0.21*,$ | 4.74 ± 0.27*,$ | 47.86 ± 1.74*,$ |
| QTN (20) | 62.75 ± 1.42*,$ | 52.28 ± 3.82*,$ | 139.30 ± 7.38*,$ | 5.78 ± 0.22*,$ | 2.67 ± 0.13*,$ | 38.88 ± 0.97*,$ |
Values in parentheses indicate a dose in mg/kg (n = 6). Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. For comparison with AIA-control group: *p < 0.05, comparison with normal group: #p < 0.05 and comparison with one another: $p < 0.05. AIA adjuvant-induced arthritis, LF leflunomide, QTN 3,5,7,3′,4′-pentahydroxy flavone, AST aspartate aminotransferase, ALT alanine transaminase, CRP c-reactive protein.