Table 1.
The drug susceptibility test was used as a standard method to evaluate the efficacy of the DNA microarray for detecting RIF and INH resistance and MDR-TB.
| CapitalBio DNA microarray | DST (n = 4148) | Sensitivity (%) | Specificity (%) | AR (%) | PPV (%) | NPV (%) | k | |
|---|---|---|---|---|---|---|---|---|
| R | S | |||||||
| RIF | ||||||||
| Overall | ||||||||
| R | 228 | 92 | 81.4 | 97.6 | 96.5 | 71.3 | 98.6 | 0.74 |
| S | 52 | 3776 | ||||||
| ≤ AFB 1 + | ||||||||
| R | 53 | 32 | 72.6 | 97.7 | 96.5 | 62.4 | 98.6 | 0.65 |
| S | 20 | 1399 | ||||||
| AFB 2 + | ||||||||
| R | 85 | 36 | 84.2 | 95.0 | 93.7 | 70.3 | 97.7 | 0.73 |
| S | 16 | 690 | ||||||
| AFB 3 + | ||||||||
| R | 44 | 13 | 84.6 | 98.2 | 97.2 | 77.2 | 99.2 | 0.79 |
| S | 8 | 695 | ||||||
| AFB 4 + | ||||||||
| R | 46 | 11 | 85.2 | 98.9 | 98.2 | 80.7 | 99.1 | 0.82 |
| S | 8 | 992 | ||||||
| INH | ||||||||
| Overall | ||||||||
| R | 324 | 108 | 74.0 | 97.1 | 94.7 | 75.0 | 96.9 | 0.72 |
| S | 114 | 3602 | ||||||
| ≤ AFB 1 + | ||||||||
| R | 113 | 40 | 67.3 | 97.0 | 93.7 | 73.9 | 95.9 | 0.67 |
| S | 55 | 1296 | ||||||
| AFB 2 + | ||||||||
| R | 80 | 25 | 74.8 | 96.5 | 93.7 | 76.2 | 96.3 | 0.72 |
| S | 27 | 695 | ||||||
| AFB 3 + | ||||||||
| R | 55 | 22 | 76.4 | 96.8 | 94.9 | 71.4 | 97.5 | 0.71 |
| S | 17 | 666 | ||||||
| AFB 4 + | ||||||||
| R | 76 | 21 | 83.5 | 97.8 | 96.6 | 78.4 | 98.4 | 0.79 |
| S | 15 | 945 | ||||||
| MDR-TB | ||||||||
| Overall | ||||||||
| R | 141 | 39 | 69.8 | 99.0 | 97.6 | 78.3 | 98.5 | 0.73 |
| S | 61 | 3907 | ||||||
| ≤ AFB 1 + | ||||||||
| R | 36 | 14 | 60.0 | 99.0 | 97.5 | 72.0 | 98.4 | 0.64 |
| S | 24 | 1430 | ||||||
| AFB 2 + | ||||||||
| R | 39 | 14 | 70.9 | 98.2 | 96.4 | 73.6 | 97.9 | 0.70 |
| S | 16 | 758 | ||||||
| AFB 3 + | ||||||||
| R | 31 | 8 | 73.8 | 98.9 | 97.5 | 79.5 | 98.5 | 0.75 |
| S | 11 | 710 | ||||||
| AFB 4 + | ||||||||
| R | 35 | 3 | 77.8 | 99.7 | 98.8 | 92.1 | 99.0 | 0.84 |
| S | 10 | 1009 | ||||||
DST drug sensitivity test, R resistant, S susceptible, AR agreement rate, PPV positive predictive value, NPV negative predictive value, AFB acid-fast bacilli.