Table 2.
The rpoB gene mutation of 320 RIF-resistant Mtb strains.
| Mutant codon(s) | Mutation type | Number | Frequency (%) |
|---|---|---|---|
| 511 | Leu511Pro | 30 | 9.4 |
| 513 | Gln513Leu | 2 | 0.6 |
| Gln513Lys | 4 | 1.3 | |
| 516 | Asp516Val | 23 | 7.2 |
| Asp516Tyr | 6 | 1.9 | |
| Asp516Gly | 3 | 0.9 | |
| 526 | His526Asp | 20 | 6.3 |
| His526Tyr | 29 | 9.1 | |
| His526Leu | 8 | 2.5 | |
| His526Arg | 8 | 2.5 | |
| 531 | Ser531Leu | 136 | 42.5 |
| Ser531Trp | 9 | 2.8 | |
| 533 | Leu533Pro | 15 | 4.7 |
| 511, 513 | Leu511Pro, Gln513Leu | 1 | 0.3 |
| 511, 516 | Leu511Pro, Asp516Gly | 2 | 0.6 |
| 511, 526 | Leu511Pro, His526Tyr | 4 | 1.3 |
| Leu511Pro, His526Asp | 1 | 0.3 | |
| 516, 526 | Asp516Gly, His526Leu | 2 | 0.6 |
| Asp516Gly, His526Asp | 3 | 0.9 | |
| Asp516Gly, His526Tyr | 1 | 0.3 | |
| 516, 531 | Asp516Val, Leu533Pro | 3 | 0.9 |
| 516, 533 | Asp516Gly, Ser531Leu | 1 | 0.3 |
| 526, 531 | His526Asp, Ser531Leu | 2 | 0.6 |
| 511, 516, 526 | Leu511Pro, Asp516Tyr, His526Leu | 1 | 0.3 |
| 516, 526, 531 | Asp516Gly, His526Asp, Ser531Leu | 1 | 0.3 |
| 511, 513, 516 ,526 | Leu511Pro, Gln513Leu, Asp516Gly, His526Leu | 3 | 0.9 |
| 511, 513, 526, 531 | Leu511Pro, Gln513Leu, His526Leu, Ser531Trp | 2 | 0.6 |
| Total | 320 | 100 |