Fig. 1.

Irradiated immunogenic tumor cell vaccine mediates protective antitumor effects. a Growth of subcutaneous EG7 tumors in C57BL/6 mice after preventive vaccination with irradiated EG7 tumor cells (IR) or PBS. b Percentage survival of EG7 tumor model mice. c, d Growth of subcutaneous LL2 tumors in C57BL/6 mice (c) and CT26 tumor in BALB/c mice (d) after preventive vaccination in the LL2 and CT26 models. Representative data are shown for three (a–d) experiments conducted with 10 (a, b) or 6–8 (c, d) mice per group. Data are represented as the mean ± SEM. *p < 0.05, **p < 0.01 (Student’s t-test)