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. 2021 Aug 27;9:642502. doi: 10.3389/fbioe.2021.642502

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Copyright © 2021 Wang, Ding, Cao, Zhang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone mesenchymal stem cells (BMSCs) promoted ECM remodeling of NPCs. NPCs of patients with IDD were cocultured with BMSCs, with NPCs cultured alone as the control. (A) miR-101-3p, Col-I, and Col-II expressions were detected using the RT-qPCR; (B) MMP-13, Col-I, Col-II, and Aggrecan levels were detected using Western blotting; (C,D) the effects of BMSCs on the viability and apoptosis of NPCs were detected using MTT assay and flow cytometry. The cell experiments were repeated three times independently. Data are presented as mean ± SD. Data in panels (A–C) were analyzed using the independent sample t-test, ***p < 0.001.