Table 5.
The variable testing methods and parameters adopted across studies of post-ICH impairment.
| Follow up times | N | Cognitive assessments | N | Imaging factors | N | Other factors | N |
|---|---|---|---|---|---|---|---|
| First assessment or stated time | Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) | 7 | Imaging | 17 | NIH Stroke Scale (NIHSS) | 8 | |
| 12 days | 1 | IQCODE ≥ 64 (dementia) | 1 | CT | 12 | Functional assessment | 8 |
| 2 weeks/14 days | 1 | IQCODE > 3.5 (impairment) | 1 | MRI | 10 | Barthel Index | 3 |
| within 3 weeks | 1 | IQCODE > 3.44 (cognitive decline) | 1 | CT/MRI | 1 | Modified Rankin Scale (mRS) | 8 |
| 3 months/90 days | 10 | IQCODE ≥ 3.4 (impairment) | 1 | Activities of Daily Living (ADL) | 1 | ||
| 6 months | 7 | 63 ≥ IQCODE ≥ 53 (impairment) | 2 | Location | 11 | Blessed Dementia Scale | 1 |
| 3–9 months | 1 | IQCODE > 3.3 (dementia) | 2 | Lobar/nonlobar ICH | 3 | Depression Assessment | 5 |
| 12 months | 6 | Mini-mental State Evaluation (MMSE) | 14 | Lobar/deep | 1 | Beck Depression Inventory | 2 |
| 18 months | 1 | MMSE < 27 (impairment) | 1 | Lobar/nonlobar/unknown | 2 | Montgomery-Asberg Depression Rating Scale (MADRS) | 3 |
| 30 months | 1 | MMSE ≤ 24 (impairment) | 1 | Lobar/deep/cerebellar/multiple | 1 | Geriatric Depression Scale | 1 |
| 3 years | 1 | MMSE < 23 (dementia) | 1 | Lobar/deep/infratentorial | 1 | Hospital Anxiety and Depression Scale | 1 |
| 40 months | 1 | 4-level assessment | 1 | Lobar/deep/cerebellar/brainstem | 1 | Hamilton Depression Rating Scale | 1 |
| Median 3.8 years | 1 | MMSE > 23 (normal) | Supratentorial/infratentorial | 1 | Race/Ethnicity African American/Not Hispanic/Not |
3 | |
| Within 4.8 years | 1 | 23 ≥ MMSE ≥ 19 (mild impairment) | Cortical/subcortical | 1 | 2 | ||
| 5 years | 1 | 18 ≥ MMSE ≥ 10 (moderate impairment) | Cortical superficial Siderosis (CSS) | 3 | 1 | ||
| 9.7 years | 1 | MMSE < 10 (severe impairment) | Presence/Absence | 1 | Previous stroke/ICH/TIA | 13 | |
| 10 years | 1 | 3-level assessment | 1 | Focal/Disseminated | 2 | Atrial Fibrillation Diabetes Mellitus |
7 |
| MMSE > 24 (normal) | Volume | 9 | 12 | ||||
| 24 ≥ MMSE > 18 | Intraventricular Extension | 7 | APOE Genotype | 3 | |||
| 18 ≥ MMSE | Microbleeds | 5 | Education level | 13 | |||
| Education-based screening assessment | 1 | White matter hyperintensity (WMH) volume | 1 | Years | 6 | ||
| MMSE < 16 (no education) | WMH Severity (Fazekas) | 8 | >8/≤ 8 years | 2 | |||
| MMSE < 23 (1–10 years education) | Enlarged Perivascular Spaces | 2 | <10/≥10 years | 1 | |||
| MMSE < 28 (11+ years education) | Lacunes | 3 | ≤ 9/>9 years | 1 | |||
| Montreal Cognitive Assessment (MoCA) | 5 | 4-level | 1 | ||||
| MoCA < 26 (impairment) | 2 | Less than high school | |||||
| MoCA ≤ 23 (impairment) | 1 | High school | |||||
| 4-level assessment | 1 | Some college | |||||
| MoCA > 26 (Normal) | College or more | ||||||
| 26 ≥ MoCA ≥ 18 (mild impairment) | 5-level | 1 | |||||
| 17 ≥ MoCA ≥ 10 (moderate impairment) | none | ||||||
| MoCA< 10 (severe impairment) | 1–6 years | ||||||
| Ascertain Dementia 8-item (AD8) ≥ 2 (impairment) | 1 | 7–9 years | |||||
| Modified MMSE (3 MSE) < 80 | 1 | 10–13 years | |||||
| Modified Telephone Interview for Cognitive Status (TICS-m) < 20 | 1 | 14+ years | |||||
| Short MoCA < 7 | 1 | Elementary only, up to 7 years before 1960, 9 years after 1960 | 1 |