Table 1:
Baseline participant characteristics by site and case-control status.
| PAMPAS | VILLA | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Cases (n= 256) | Controls (n= 152) | p value | Cases (n= 180) | Controls (n= 139) | p value | |
| Demographic characteristics | ||||||
|
| ||||||
| Age (years), mean (SD) | 13.5 (2.7) | 13.8 (2.6) | 0.28 | 13.3 (2.6) | 12.8 (2.7) | 0.07 |
| Male, n (%) | 151 (59) | 73 (48) | 0.03 | 94 (52) | 65 (47) | 0.33 |
| a, bSES, mean (SD) | −0.35 (1.6) | −0.81 (1.6) | 0.005 | 0.92 (1.4) | 0.38 (1.5) | 0.001 |
| cTotal IgE, kU/L (%) | 1202 (1523) | 599 (758) | <0.001 | 1257 (1498) | 658 (1092) | <0.001 |
| d Atopic Diseases, n (%) | ||||||
| Eczema | 36 (14.6) | 19 (13.2) | 0.69 | 17 (10.3) | 3 (2.2) | 0.005 |
| Rhinitis | 21 (15.2) | 2 (3.7) | 0.03 | 21 (20.4) | 1 (3.1) | 0.02 |
| Ancestry, mean (SD) | ||||||
| Indigeneous (NAT) | 85.7 (9.2) | 86.8 (9.7) | 0.22 | 82.0 (10.3) | 83.9 (9.6) | 0.10 |
| European (IBS) | 14.3 (9.2) | 13.2 (9.7) | 0.22 | 18.0 (10.3) | 16.1 (9.6) | 0.10 |
|
| ||||||
| Clinical characteristics | ||||||
|
| ||||||
| BMI, n (%) | ||||||
| eUnderweight/Normoweight | 146 (57.0) | 102 (67.1) | 0.10 | 77 (42.8) | 83 (59.7) | 0.01 |
| Overweight | 77 (30.1) | 32 (21.1) | 66 (36.7) | 37 (26.6) | ||
| Obese | 33 (12.9) | 18 (11.8) | 37 (20.6) | 19 (13.7) | ||
| Baseline FEV1 (percent predicted), mean (SD) | 114.1 (14.5) | 118.4 (13.8) | 0.003 | 113.6 (15.6) | 119.2 (13.9) | <0.001 |
| Baseline FEV1 (raw) in liters, mean (SD) | 2.86 (0.82) | 3.03 (0.80) | 0.04 | 2.86 (0.78) | 2.80 (0.77) | 0.48 |
| Baseline FEV1 (Z-score), mean (SD) | 1.22 (1.25) | 1.58 (1.20) | 0.004 | 1.18 (1.34) | 1.66 (1.22) | <0.001 |
| Asthma severity, n (%) | ||||||
| Mild intermittent | 40 (20.4) | N/A | N/A | 31 (22.6) | N/A | N/A |
| Mild persistent | 82 (41.8) | N/A | 64 (46.7) | N/A | ||
| Moderate persistent | 41 (20.9) | N/A | 23 (16.8) | N/A | ||
| Severe persistent | 33 (16.8) | N/A | 19 (13.9) | N/A | ||
| Sensitivity to environmental allergens, n (%) | ||||||
| House dust mix (D.pter, D. far, Bla g) | 195 (76) | 88 (58) | 0.001 | 132 (73) | 76 (55) | <0.001 |
| Mold and yeast mix (pen, clad, asp, candida, alternaria, setomelanomma( | 154 (62) | 49 (35) | <0.001 | 76 (42) | 35 (25) | 0.001 |
| Animal and epidermal mix (Can f, Fel d, Mus m1, rat, guinea pig) | 118 (46) | 30 (20) | <0.001 | 79 (44) | 28 (20) | <0.001 |
| Exhaled Exhaled nitric oxide, eNO (ppb), median [IQR] | 37.1 (34.9) | 21.7 (24.6) | <0.001 | 44.2 (41.0) | 24.3 (31.1) | <0.001 |
SD: standard deviation
a b
Socioeconomic status score based on a principal component analysis, which includes 12 household assets, parental level of education, and number of persons in the household. Higher number denotes higher socioeconomic status
c
All IgE levels in the samples were above level of assay detection
d
Eczema (390 in Pampas, 300 in Vila (690 of 727 subjects)) and rhinitis (192 in Pampas, 135 in Vila (327 of 727 subjects)) data collected only on subset of patients
e
Between both sites, only 3 individuals fell into the ‘Underweight’ category