TABLE II.
Genetic variants passing the GWAS threshold (P < 5 × 10−8) for any of the 3 phenotypes of asthma, total serum IgE level, and lung function
| rslD | Chr | hg19 Position | Ref/Alt | MAF | Genotyped | R 2 | Nearby gene(s) | Asthma |
log10 (total serum IgE) |
Lung function |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P value | Effect size | P value | Effect size | P value | ||||||||
|
| |||||||||||||
| rs6913471 | 6 | 32339925 | T/A | 0.273 | Imputed | 0.955 | 0.965605416 | .7811 | 0.215 | 4.93E–08 | −1.099 | .2016 | |
| rs4496841 | 6 | 32389997 | C/T | 0.719 | Imputed | 0.988 | 0.854704059 | .1852 | −0.209 | 1.39E–08 | 1.363 | .08916 | |
| rs3135359 | 6 | 32390578 | T/C | 0.736 | Imputed | 0.995 | 0.878973966 | .2832 | −0.218 | 5.33E–09 | 1.147 | .1599 | |
| rs9296027 | 6 | 32393062 | C/G | 0.241 | Imputed | 0.995 | 1.093080656 | .4805 | 0.218 | 2.74E–08 | −1.303 | .1278 | |
| rs9469109 | 6 | 32393161 | A/T | 0.241 | Imputed | 0.995 | 1.094174284 | .4793 | 0.218 | 2.73E–08 | −1.304 | .1275 | |
| rs3135348 | 6 | 32394098 | A/G | 0.687 | Imputed | 0.966 | 0.922193691 | .4957 | −0.229 | 3.44E–10 | 1.464 | .06675 | |
| rs9501400 | 6 | 32394184 | G/A | 0.247 | Imputed | 0.996 | 1.112934254 | .398 | 0.221 | 1.50E–08 | −1.433 | .09281 | |
| rs9501622 | 6 | 32394251 | T/A | 0.241 | Imputed | 0.998 | 1.095269005 | .4695 | 0.218 | 2.64E–08 | −1.311 | .1254 | |
| rs732163 | 6 | 32394911 | G/A | 0.24 | Imputed | 1.000 | 1.11516235 | .3907 | 0.218 | 2.70E–08 | −1.213 | .1563 | |
| rs4959100 | 6 | 32397813 | C/T | 0.237 | Imputed | 1.000 | 1.122995872 | .3612 | 0.216 | 4.63E–08 | −1.358 | .1152 | |
| rs9469110 | 6 | 32398525 | G/T | 0.237 | Genotyped | 1.000 | 1.122995872 | .3613 | 0.216 | 4.64E–08 | −1.358 | .1151 | |
| rs3129854 | 6 | 32398781 | G/C | 0.719 | Imputed | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| NA | 6 | 32398853 | T/TA | 0.719 | Imputed | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs984778 | 6 | 32400088 | C/T | 0.719 | Genotyped | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs9501626 | 6 | 32400344 | C/A | 0.237 | Genotyped | 1.000 | 1.122995872 | .3613 | 0.216 | 4.64E–08 | −1.358 | .1151 | |
| rs3135338 | 6 | 32401217 | C/T | 0.719 | Genotyped | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs3135336 | 6 | 32401829 | G/A | 0.72 | Imputed | 0.995 | 0.860707976 | .2091 | −0.225 | 1.16E–09 | 1.238 | .1254 | |
| rs3135335 | 6 | 32401845 | C/G | 0.72 | Imputed | 0.995 | 0.860707976 | .2091 | −0.225 | 1.16E–09 | 1.238 | .1254 | |
| rs2027856 | 6 | 32402705 | G/A | 0.237 | Genotyped | 1.000 | 1.122995872 | .3613 | 0.216 | 4.64E–08 | −1.358 | .1151 | |
| rs3135397 | 6 | 32403941 | A/T | 0.719 | Imputed | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs3129866 | 6 | 32404065 | G/C | 0.719 | Imputed | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs3129867 | 6 | 32404220 | G/C | 0.723 | Imputed | 0.999 | 0.884263663 | .3042 | −0.22 | 2.57E–09 | 1.243 | .1233 | |
| rs2395173 | 6 | 32404859 | A/G | 0.719 | Genotyped | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs3135395 | 6 | 32405192 | T/G | 0.719 | Genotyped | 1.000 | 0.862431115 | .2136 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs2395178 | 6 | 32405362 | G/C | 0.719 | Imputed | 1.000 | 0.862431115 | .2138 | −0.224 | 1.16E–09 | 1.231 | .1263 | |
| rs3129869 | 6 | 32405671 | A/C | 0.72 | Genotyped | 0.999 | 0.863293977 | .2186 | −0.224 | 1.09E–09 | 1.237 | .1244 | |
| rs3129871 | 6 | 32406342 | A/C | 0.709 | Imputed | 0.999 | 0.832768156 | .1245 | −0.211 | 1.05E–08 | 1.153 | .1516 | |
| rs9271364 | 6 | 32586787 | A/G | 0.689 | Imputed | 1.000 | 0.923116346 | .5037 | −0.201 | 4.97E–08 | 0.497 | .5375 | |
| rs9272518 | 6 | 32606446 | G/T | 0.495 | Imputed | 0.701 | HLA-DQA1 | 1.044982355 | .7238 | −0.228 | 4.78E–09 | 1.725 | .04204 |
| rs9273395 | 6 | 32627094 | C/T | 0.634 | Imputed | 0.936 | 0.88603396 | .3118 | −0.206 | 3.47E–08 | 1.365 | .09296 | |
| rs4335869 | 19 | 56085656 | T/A | 0.297 | Imputed | 0.872 | 1.065026839 | .6251 | −0.022 | .5873 | 5.489 | 1.33E–10 | |
| NA | 19 | 56086758 | GA/GAA | 0.328 | Imputed | 0.848 | 1.030454534 | .8187 | −0.023 | .5706 | 5.433 | 1.43E–10 | |
| rs28699417 | 19 | 56087272 | T/C | 0.323 | Imputed | 0.887 | 1.034584607 | .7907 | −0.021 | .6048 | 5.279 | 2.54E–10 | |
| rs28379489 | 19 | 56087281 | T/A | 0.323 | Imputed | 0.887 | 1.035619709 | .7818 | −0.021 | .6044 | 5.276 | 2.65E–10 | |
| NA | 19 | 56088110 | C/CA | 0.249 | Imputed | 0.593 | 1.09089668 | .6007 | −0.025 | .6331 | 6.372 | 5.19E–09 | |
| rsl 2972695 | 19 | 56088487 | A/G | 0.33 | Imputed | 0.892 | 1.010050167 | .9379 | −0.026 | .5089 | 5.144 | 4.73E–10 | |
| rsl 0403008 | 19 | 56089947 | C/G | 0.307 | Imputed | 0.903 | ZNF579 | 1.057597684 | .6543 | −0.009 | .8208 | 5.211 | 3.39E–10 |
| rs34164618 | 19 | 56090076 | G/T | 0.306 | Imputed | 0.903 | ZNF579 | 1.071436209 | .5838 | −0.009 | .8128 | 5.271 | 2.44E–10 |
| rsl 2609355 | 19 | 56105932 | G/A | 0.3 | Imputed | 0.904 | FIZ1 | 1.108491409 | .4255 | −0.014 | .7245 | 5.195 | 1.14E–09 |
| rs3803890 | 19 | 56110700 | G/A | 0.288 | Imputed | 0.879 | FIZ1 | 1.133148453 | .3485 | −0.008 | .8501 | 5.369 | 8.98E–10 |
| rs4410198 | 19 | 56122538 | G/A | 0.296 | Imputed | 0.832 | ZNF865 | 1.087628894 | .5364 | 0.001 | .9873 | 5.83 | 5.54E–11 |
| rsl 46619376 | 19 | 56127441 | C/G | 0.277 | 0.854 | ZNF865 | 1.068226717 | .626 | −0.006 | .8831 | 5.351 | 2.51E–09 | |
Alt, Alternative; NA, not available; OR, odds ratio; Ref, reference; rsID, rs identifier.
A strong association with the previously implicated HLA-DR/DQ región on Chr6 with total serum IgE level was identified, as was a novel locus mapping to chromosome 19, near zinc finger interacting genes for lung function. Boldface indícales significance at the P < 5 × 10−8 threshold.