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. 2021 Sep 9;43(1):34. doi: 10.1186/s40902-021-00320-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Hematoxylin and eosin stain (original magnification ×40). A Histologic finding of the control group after 2 weeks (FCT fibrous connective tissue). B Histologic finding of the DDM group after 2 weeks (→ osteoblast, FCT fibrous connective tissue). C Histologic finding of the PRF/DDM group after 2 weeks (→ osteoblast, OT osteoid tissue, ★ blood vessel, FCT fibrous connective tissue, NFB newly formed bone). D Histologic finding of the rhBMP2/DDM group after 2 weeks (→ osteoblast, OT osteoid tissue, ☆ cluster of fibroblast, ◆ osteocyte, : resorbed DDM, ▲ osteoclast, NFB newly formed bone). E Histologic finding of the control group after 4 weeks (→ osteoblast, ◆ osteocyte, OT osteoid tissue, FCT fibrous connective tissue). F Histologic finding of the DDM group after 4 weeks (→ osteoblast, OT osteoid tissue, ★ blood vessel, ☆ cluster of fibroblast, FCT fibrous connective tissue, NFB newly formed bone). G Histologic finding of the PRF/DDM group after 4 weeks (: resorbed DDM, OT osteoid tissue, NFB newly formed bone). H Histologic finding of the rhBMP2/DDM group after 4 weeks (→ osteoblast, OT osteoid tissue, ◆ osteocyte, : resorbed DDM, NFB newly formed bone). I Histologic finding of the control group after 8 weeks (→ osteoblast, ◆ osteocyte, GT granulation tissue, NFB newly formed bone). J Histologic finding of the DDM group after 8 weeks (NFB newly formed bone). K Histologic finding of PRF/DDM group after 8 weeks (: resorbed DDM, NFB newly formed bone). L Histologic finding of the rhBMP2/DDM group after 8 weeks (: resorbed DDM, → osteoblast, OT osteoid tissue, ◆ osteocyte, : resorbed DDM, ▲ osteoclast, NFB newly formed bone)