Table 2.
Demographics and biomarkers.
| BMM index | < 1 | ≥ 1 | p* |
|---|---|---|---|
| n | 31 | 15 | |
| Age (years) | 69 [62, 74] | 73 [68, 75] | 0.23 |
| Sex (female) | 15/31 (48%) | 8/15 (53%) | 1 |
| BMI | 21 [19, 23] | 21 [19, 22] | 0.57 |
| ΔBMI(/M) | − 0.02 [− 0.19, 0.00] | − 0.25 [− 0.31, − 0.16] | 0.004 |
| Excess weight loss (yes)† | 6/31 (19%) | 6/15 (40%) | 0.165 |
| Time since onset (M) | 17 [12, 32] | 8 [8, 11] | 0.005 |
| ALSFRS-R | 41 [36, 45] | 38 [34, 42] | 0.196 |
| ΔALSFRS-R | 0.44 [0.16, 0.72] | 0.88 [0.59, 1.5] | 0.003 |
| Bulbar type (yes) | 6/31 (19%) | 6/15 (40%) | 0.165 |
| LDL (mg/dl) (n) | 122 [102, 143] (27) | 98 [91. 103] (12) | 0.011 |
| %VC (%) (n) | 90 [82, 98] (30) | 78 [55, 86] (14) | 0.002 |
| mREE/pREE | 1.07 [1.00, 1.11] | 1.06 [1.00, 1.21] | 0.66 |
| RQ < 0.85 (yes) | 20/31 (65%) | 8/15 (53%) | 0.53 |
| High-fat (yes) | 22/31 (71%) | 10/15 (67%) | 1 |
| Lean soft tissue mass (kg) | 36 [31, 42] | 31 [28, 37] | 0.143 |
| SMI (kg/m2) | 6.0 [5.2, 6.8] | 5.5 [4.5, 6.1] | 0.073 |
| PEG (yes) | 14/31 (45%) | 10/15 (67%) | 0.22 |
| NPPV (yes) | 20/31 (65%) | 7/15 (47%) | 0.22 |
| Endpoint (yes) | 11/31 (35%) | 10/15 (67%) | 0.063 |
Bold font was used to strengthen the statistical significance.
Data presented as median [Interquartile range]. (n) shows the number of patients in factors that have missing values.
BMM BMI-muscle metabolism, BMI Body mass index, ALSFRS-R Revised amyotrophic lateral functional rating scale, LDL Low-density lipoprotein cholesterol, VC Vital capacity, REE Resting energy expenditure, mREE Measured REE, pREE Predicted REE, RQ Respiratory quotient, SMI Skeletal muscle index, PEG Percutaneous endoscopic gastrostomy, NPPV Non-invasive positive pressure ventilation.
*p value is based on Fisher's exact test or Mann–Whitney U test.
†Excess weight loss means more than 10% compared to the body weight before the illness.